ADME-PK Services

SynSmart provides comprehensive ADME-PK insights through in vitro and in vivo studies, helping characterize the key properties and behavior of drug candidates. These insights support early identification of liabilities, informed candidate selection, and effective molecular optimization throughout the discovery journey.
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ADME-PK Services
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About the service
SynSmart provides comprehensive ADME-PK support to generate critical insights into the absorption, distribution, metabolism, and pharmacokinetic properties of drug candidates. Our capabilities span in vitro and in vivo studies, enabling the assessment of solubility, stability, metabolic behavior, protein binding, CYP interactions, permeability, and pharmacokinetic profiles. These studies help identify potential liabilities early, guide compound optimization, and support informed decision-making as programs progress from discovery toward development.

DMPK Services

Integrated DMPK capabilities

In vitro screening and in vivo pharmacokinetic studies designed to support confident decisions throughout drug discovery and development.

Pharmacokinetic Studies

DMPK — In vivo

07Studies

Single Dose PK Studies

Cross Over Studies

Multiple Dose PK Studies

Toxicokinetic Studies

Dose Range Finding Studies

Dose Escalation Studies

Maximum Tolerable Dose Studies

ADME Screening Assays

DMPK — In vitro

15Assays

Kinetic Solubility

Thermodynamic Solubility

LogD

Plasma Stability Study

Protein Binding Study

Microsomal Metabolic Stability

Blood to Plasma Ratio Determination

Chemical Stability Study

Direct CYP Inhibition Studies

CYP Time Dependent Inhibition Studies

PAMPA

Hepatocyte Metabolic Stability

CYP Induction

Caco-2

MDCK

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Journey with SynSmart

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