Process Research & Scale-Up

SynSmart brings deep expertise in developing and scaling up chemical processes, with established capabilities across a broad portfolio of reaction chemistries — from classical transformations to high-pressure and high-temperature reactions.
Home
Services
Process Research & Scale-up
Pharmaceutical technician in sterile environment at pharmacy industry
Innovative Chemistry Technologies
About the service

Robust process development for reliable scale-up

SynSmart offers process research and scale-up services to help partners efficiently bridge the gap between research and commercialization. Our process research team works to develop robust and cost-effective synthetic routes, identifying high-impact opportunities to improve yield, efficiency, and overall process economics. We support the scaling of compounds from laboratory quantities to kilogram scale, while focusing on process consistency, product quality, and reliable scalability. This structured approach helps reduce development timelines, manage costs, and establish processes that are better suited for larger-scale production.
Core Capabilities

Core Process Capabilities

End-to-end process development from route scouting through analytical methods and impurity management.

Route Scouting & Development

Designing synthetic routes based on prior art and combined wisdom. Selection and screening based on raw material availability, safety, economics and robustness.

Process Optimization & Scale-Up

Developing scalable manufacturing processes using DoE/QbD methodologies. Identifying critical process parameters (CPP), Proven Acceptable Range (PAR) and Normal Acceptable Range (NOR).

Analytical Methods & Quality Control

Developing analytical methods and quality control procedures. Preparing comprehensive technology transfer packages for manufacturing.

Reference Standards & Impurities

Impurity characterization and management. Reference standard preparation and characterization to ensure product quality and compliance.

Reaction Expertise

A broad portfolio of classical and specialized reaction chemistries, developed and scaled with precision.

Grignard Reactions

Organomagnesium (R–MgX) reagent chemistry, carried out under strict anhydrous conditions.

Reduction

Selective reductions using NaBH₄ and LiAlH₄.

Friedel–Crafts Reaction

Electrophilic aromatic alkylation and acylation using AlCl₃ or FeCl₃.

Chlorination

Chlorination using SOCl₂, POCl₃, HCl, and Cl₂.

Bromination

Bromination using bromine or HBr in acetic acid.

High-Pressure Hydrogenation

Pd/C, Pt/C, and Raney Ni at pressures up to 15 bar.

High-Temperature Reactions

Thermal reaction capabilities at temperatures up to 200 °C.

Nitration

Nitration using HNO₃ and H₂SO₄ mixed-acid systems.

Sulfonation

Sulfonation using SO₃H and oleum.

Chiral Resolutions

Established resolution chemistry for chiral compounds.

Alkylation & Acylation

Chain and acyl-group installation using R–X and R–COCl reagents.

N-BuLi, sec-BuLi & Dimethyl Zinc

Organolithium and organozinc transformations under inert, low-temperature conditions.

Amination

Amination using ammonia and primary or secondary amines.

Condensation

Aldol and Claisen-type condensation chemistry.

Oxidation

Selective, controlled oxidation reactions.

Suzuki & Heck Coupling

Established Pd-catalyzed coupling capabilities for complex synthesis.

Diazotization

Low-temperature diazotization using NaNO₂ at 0–5 °C.

Azidation

Controlled azidation chemistry using NaN₃.

Reductive & Chiral Aminations

Specialized amination methodologies, including reductive and chiral approaches.

Cyanation

Cyanation using NaCN, KCN, and CuCN.

Accelerate Your Chemistry
Journey with SynSmart

Let's Start a Conversation

Tell us about your project and our experts will get back to you with the right solution.
Share your requirements, project goals, or specific chemistry challenges.