Manufacturing
Our approach combines deep synthetic chemistry expertise, process understanding, analytical
support and manufacturing execution to deliver the right product at the right scale, with a strong
focus on quality, safety, reproducibility and cost efficiency.
Manufacturing Infrastructure
Challenging chemistry. Larger-volume production.
Our manufacturing infrastructure supports challenging chemistry and larger-volume production.
Key capabilities
- Walk-in fume hoods
- Glass-lined reactors from 5 L to 200 L
- Stainless-steel and glass-lined reactors from 500 L to 3,000 L
- Pressure reactors from 2,000 L to 3,000 L
- Temperature control from −40°C to +250°C
- Chilling systems
- Tray and vacuum tray drying
This infrastructure enables us to handle a broad range of synthetic transformations, including high-temperature and pressure reactions, hydrogenation, halogenation, Grignard chemistry, nitration, reductions, oxidations, metal-mediated couplings and other challenging reactions.
Non-GMP Manufacturing
In-house expertise. Qualified external capacity.
SynSmart supports the manufacture and supply of non-GMP drug substances, key starting materials (KSMs), building blocks and advanced intermediates, with a safety-first approach and compliance with applicable EHS requirements.
Our manufacturing model combines in-house process and manufacturing expertise with access to qualified external manufacturing capacity. Through a hub-and-spoke model, we can provide access to manufacturing capacities in the 2,000–3,000 L range, while maintaining scientific and project oversight through our in-house team.
Reactions at Scale
Complex synthesis and demanding chemistry
Our scientists have experience with a wide range of demanding chemistry, including:
Complex Synthetic Chemistry
- Heterocyclic and fused-ring systems
- Multi-step synthetic routes
- Asymmetric and chiral synthesis
- Complex building blocks and intermediates
Challenging Reactions
- Transition-metal-mediated coupling reactions
- Suzuki, Heck, Negishi and Buchwald-Hartwig chemistry
- Grignard and organometallic reactions
- Catalytic hydrogenation
- Halogenation and fluorination
- Nitration, oxidation and reduction
- Cryogenic chemistry
- High-temperature and pressure reactions
- Reactions involving gaseous and sensitive reagents
New Frontier
Continuous Flow Chemistry
SynSmart also leverages continuous flow chemistry for selected reactions where continuous processing can provide advantages over conventional batch chemistry.
Our flow capabilities support temperatures up to 250°C, pressures up to 50 bar, and throughput of approximately 35–36 L/day. Flow chemistry has enabled SynSmart to deliver selected processes from g-scale to 100s kg-scale, with benefits including improved conversion, selectivity, short residence times, enhanced safety, and scalability.
Quality, Safety & IP Protection
Safety and quality, integral to our approach
Safety and quality are integral to our manufacturing approach.
Our systems include
- Periodic quality-system reviews
- Internal quality audits
- Project-specific and ongoing employee training
- Defined quality goals and periodic review
- EHS and process-safety assessments
- Strict PPE and safety practices
- Controlled access to laboratory and manufacturing environments
- Customer-focused IP ownership and confidentiality provisions
We maintain controlled information-sharing practices and a strong safety culture across our research, scale-up and manufacturing activities.
Partner with SynSmart for process development, scale-up and cost-effective manufacturing of complex molecules and intermediates.
Accelerate Your Chemistry
Journey with SynSmart
Let's Start a Conversation
Tell us about your project and our experts will get back to you with the right solution.
Share your requirements, project goals, or specific chemistry challenges.
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SynSmart Rasayan Research, Navi Mumbai,
Maharashtra 400701, India - bd@synsmart.in
- +91 84540 99758
