SynSmart offers a vast range of synthetic chemistry services through an experienced scientific team with the aim of accelerating diverse synthetic and drug discovery needs of innovator biotech and pharmaceutical companies across the globe. With our skills of tackling complex synthetic routes with different approaches, we endeavor for synthesizing high quality compounds at rapid speed. SynSmart works on early-stage discovery projects for pharma/ biotech customers in making intermediates, building blocks and final compounds from mg to multi-g scale.Â
SynSmart offers chemistry services under flexible business arrangements including Fee for Service (FFS), Time & Material based arrangement or Full-Time Equivalent (FTE) based.
Our expertise in synthetic chemistry
Traditional Heterocyclic Chemistry
Synthesis of O, N, S and P heterocyclic and fused-ring analogues, Benzofuran formation, Azaindole Chemistry, Thiophene ring formation, Thiazole formation etc.
Transition Metal-mediated Reactions
Suzuki coupling, Negishi & Heck Coupling, Buchwald-Hartwig Coupling, Phosphonate Chemistry, C-P, C-S, C-B, C-Sn and C-Si bond forming reactions, C-H activations etc.
Difficult-to-handle and Sensitive Reagents
Including all kinds of metal-based pyrophoric reagents like lithium, magnesium and zincs, toxic reagents like metallic cyanides and metal carbonyls e.g., Reduction, Catalytic hydrogenation, Grignard, Hydroxymethylation etc.
Handling of Gaseous Reagents
Experienced in reactions involving gases like H2, Cl2 , O2 , CO, CO2, SO3 etc. – in addition to rarer reactions like ozonolysis – even at larger scales. e.g. Chloromethylation, Bromination & Selective Reduction, all types of Halogenation
High-temperature reactions at 290 °C
Nitration, Reduction and Migration
Special Synthetic reactions
Cryogenic Reactions, Use of pyrophoric reagents, fluorinations, synthesis of fluoroalkyl and fluoro alkoxy targets, cyclopropanations, deuterations, labeling and isotope synthesis and much more.
Our chemical synthesis capabilities
- Library and analogs: We have an experience in synthesis of a variety of libraries ranging between focused libraries 10-100 members. Our capabilities include synthesizing libraries, synthesis of scaffolds/building blocks including complex structure involving multi-step synthesis
- Catalyst screening: We have capabilities of synthesis and screening of different catalysts, e.g. Iridium complexes, Vanadium complexes etc.
- Nucleotides: SynSmart team has the ability to synthesize a wide variety of molecules, including nucleotides and nucleosides.
- Protein degraders (PROTACs): Chemistry of PROTACs and partial PROTACs. Our team of experienced organic chemists can tackle the synthesis of heterobifunctional target molecules used for Protein Degradation.
- Asymmetric synthesis/Chiral Pool synthesis: Asymmetric aldol and related reactions, asymmetric Diels-alder reaction, asymmetric transfer hydrogenation, asymmetric reductions, asymmetric dihydroxylation, amino hydroxylation, symmetric hydrosilylation, resolution of racemic mixture.
- Carbohydrates: Our team has experience of synthesis of a wide range of carbohydrate-based compounds.
- Chiral Separation: We have capability to separate chirally pure compounds via crystallization, resolution, prep HPLC purification.
- Metabolites: We are experts in metabolite synthesis.
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