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    PRECLINICAL RESEARCH in collaboration with Vivo Biotech Ltd

    Synsmart now offers a wide range of DMPK services in collaboration with Vivo Biotech ltd to support lead optimization, preclinical development & safety assessment studies (Toxicology)

    Our Partner  Vivo Biotech Ltd is having proven track record.

    • One of the Largest (1,25,000 Sq. ft.) standalone preclinical research facilities.
    • Capable of adding 25,000 Sq. ft. space subsequently.
    • State of the art facilities with Modern and Sophisticated Instruments/Equipments.
    • Pioneer and largest specific pathogen free (SPF) certified lab animal supplier in India.
    • 450+ clientele; 250+ human resources employed.
    • Successfully submitted studies under GLP to 20+ countries.
    • Employees includes postgraduates, veterinarians, Phds , DABTs

    Industries we served

    Toxicology Services

    • Toxicology (In-vivo)
    • Acute
      1. Acute (All routes of administration)
      (OECD 402, 420, 423, 425)
      2. Skin Irritation / Sensitisation (OECD 406)
      3. Dermal Irritation / Corrosion (OECD 404)
      4. Eye Irritation (OECD 405)
    • Dose Range Finding (DRF) /Maximum Tolerated Dose (MTD)
    • Sub-Acute (OECD 407)
    • Sub-Chronic (OECD 408,409)
    • Reproductive Toxicity
      1. Male Fertility
      2. Prenatal Development / Teratology (OECD 414)
      3. One Generation Reproduction (OECD 415)
    • Toxicokinetics (OECD 417)

    • Toxicology (In-vitro)
    • Cytotoxicity Assay (MTT Assay) (ISO 10993-5:2009(E))
    • 3T3-NRU Assay (OECD 432)
    • HET-CAM Test

    • Mutagenicity
    • Bacterial Reverse Mutation Test (AMES Test) (OECD 471)
    • In Vitro Mammalian Chromosome Aberration Test (OECD 473)
    • Mammalian Erythrocyte Micronucleus Test (OECD 474)
    • Mammalian Bone Marrow Chromosome Aberration Test (OECD 475)
    • In Vitro Mammalian Cell Gene Mutation Test (OECD 476)
    • In Vitro Mammalian Cell Micronucleus Test (OECD 487)

    ADME-PK Services

    • DMPK - In vivo
    • Single Dose PK Studies
    • Cross Over Studies
    • Multiple Dose PK Studies
    • Toxicokinetic Studies
    • Dose Range Finding Studies
    • Dose Escalation Studies
    • Maximum Tolerable Dose Studies

    • DMPK - In vitro
    • Kinetic Solubility
    • Thermodynamic Solubility
    • LogD
    • Plasma Stability Study
    • Protein Binding Study
    • Microsomal Metabolic Stability
    • Microsomal Metabolic Stability
    • Blood to Plasma Ratio Determination
    • Chemical Stability Study
    • Direct CYP Inhibition Studies
    • CYP Time Dependent Inhibition Studies
    • PAMPA
    • Hepatocyte Metabolic Stability
    • CYP Induction
    • Caco-2
    • MDCK